🔬 Uses and Benefits

PANRIDEN DSR is primarily used to treat:

1. Gastroesophageal Reflux Disease (GERD): Manages symptoms like heartburn, chest pain, and acid regurgitation
2. Peptic Ulcer Disease: Helps heal ulcers in the stomach and duodenum
3. Acid Reflux: Reduces the backward flow of stomach acid into the esophagus
4. Indigestion (Dyspepsia): Relieves discomfort, bloating, and pain associated with excess stomach acid
5. Nausea and Vomiting: The domperidone component helps control these symptoms
6. Zollinger-Ellison Syndrome: Manages excessive acid production in this rare condition

Key benefits include:

• Fast and effective relief from heartburn and acid reflux
• Promotes healing of damaged esophageal tissue
• Improves digestion by enhancing gastric emptying
• Prevents recurrence of acid-related symptoms
• Reduces the need for multiple medications

📖 Instruction for Use

1. Take PANRIDEN DSR exactly as prescribed by your doctor
2. Take it on an empty stomach, preferably in the morning 30 minutes before breakfast
3. Swallow the capsule whole with a glass of water; do not crush, chew, or break it
4. The usual dosage is one capsule daily, but follow your doctor's specific instructions regarding dose and duration
5. For best results, take the medication at the same time each day
6. Complete the full course of treatment even if symptoms improve before completion
7. Avoid alcohol, spicy foods, and caffeinated beverages while on this medication as they may reduce its effectiveness
8. If using antacids, take them at least 2 hours before or after PANRIDEN DSR

⏱️ Forget/Missed Doses

If you miss a dose of PANRIDEN DSR:

• If remembered within 12 hours: Take the missed dose as soon as you remember
• If more than 12 hours have passed: Skip the missed dose and take your next dose at the regular time
• Do not double dose: Never take two doses to make up for a missed one

If you frequently forget doses, consider setting a daily alarm reminder or asking someone to help you remember.

🧬 How this Works

Pantoprazole (40mg):

• Acts as a proton pump inhibitor (PPI)
• Irreversibly binds to the H+/K+-ATPase enzyme system (the "proton pump") in gastric parietal cells
• Blocks the final step of acid production, significantly reducing stomach acid levels by up to 90%
• Provides relief from acid-related symptoms and creates an environment that allows ulcers and damaged tissue to heal

Domperidone (30mg):

• Works as a dopamine receptor antagonist primarily in the peripheral nervous system
• Blocks D2 receptors in the gastrointestinal tract, increasing stomach and intestinal motility
• Promotes faster gastric emptying, preventing the backup of stomach contents
• Helps reduce nausea and vomiting through its action on the chemoreceptor trigger zone
• Improves overall digestive coordination and prevents reflux of stomach contents

Together, these components address both the excessive acid production and the impaired stomach motility that often contribute to GERD and related conditions, providing a more comprehensive approach than either medication alone.

🛡️ Storage

To maintain the effectiveness of PANRIDEN DSR:

1. Store at room temperature (20°C to 25°C or 68°F to 77°F)
2. Keep the medication in its original container, tightly closed
3. Store in a dry place, away from moisture and direct sunlight
4. Keep out of reach of children and pets
5. Do not use the medication after the expiry date printed on the package
6. Do not store in the bathroom or other places with high humidity

⚠️ Side Effects

Common side effects may include:

• Headache
• Dizziness
• Diarrhea or constipation
• Stomach pain or discomfort
• Nausea
• Dry mouth
• Flatulence (gas)
• Joint pain
• Fatigue

Less common but more serious side effects (seek medical attention if experienced):

• Irregular heartbeat (higher risk in patients over 60 years)
• Severe allergic reactions (rash, itching, swelling, severe dizziness)
• Severe stomach pain
• Unusual tiredness or weakness
• Muscle spasms or tremors
• Signs of low magnesium (muscle cramps, irregular heartbeat)
• Signs of vitamin B12 deficiency (weakness, fatigue, numbness/tingling)
• Involuntary movements (extrapyramidal effects)
• Severe skin reactions like Stevens-Johnson syndrome

🔁 Over Doses

Symptoms of overdose may include:

• Severe drowsiness
• Confusion
• Severe headache
• Severe nausea or vomiting
• Rapid or irregular heartbeat
• Muscle spasms or movement disorders

In case of overdose, seek immediate medical attention or contact a poison control center.

💡 Safety Advice

Pregnancy and Breastfeeding:

• Not recommended during pregnancy unless clearly needed
• The medication may pass into breast milk, so caution is advised while breastfeeding
• Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding

Alcohol:

• Avoid alcohol consumption while taking PANRIDEN DSR
• Alcohol can increase the risk of stomach damage and worsen side effects
• May reduce the effectiveness of the medication

Driving and Operating Machinery:

• May cause dizziness and drowsiness in some patients
• Avoid driving or operating machinery until you know how the medication affects you
• Take extra precaution if you experience side effects that affect concentration

Pre-existing Conditions:

• Inform your doctor if you have liver or kidney disease
• Use with caution in patients with heart conditions due to potential for heart rhythm changes
• Not suitable for patients with certain gastrointestinal conditions like intestinal obstruction
• May interact with certain medications, so inform your doctor about all medicines you are taking

Long-term Use:

• Prolonged use may lead to vitamin B12 and magnesium deficiency
• Long-term use may slightly increase risk of bone fractures, especially in older adults
• Regular monitoring for nutrient deficiencies may be necessary with extended use
• Follow up with your doctor for periodic assessment if using for more than 8 weeks

Special Precautions

1. Vitamin B12 Deficiency: Long-term use may lead to vitamin B12 deficiency, particularly in elderly patients. Consider periodic blood tests if used for more than 3 months.
2. Magnesium Levels: Monitor for signs of hypomagnesemia (irregular heartbeat, muscle spasms) with prolonged use.
3. Heart Rhythm Issues: Use with caution in patients with heart conditions or those taking medications that affect heart rhythm. Domperidone may increase the risk of irregular heartbeat in susceptible individuals.
4. Bone Fractures: Long-term use of pantoprazole component may slightly increase risk of hip, wrist, or spine fractures.
5. Kidney Function: Use with caution in patients with kidney problems; dose adjustments may be necessary.
6. Liver Function: Dose adjustment may be needed in patients with severe liver disease.
7. Elderly Patients: May be more susceptible to side effects, particularly heart-related issues from domperidone.

Remember to keep all follow-up appointments with your doctor to monitor your progress and address any potential side effects or complications.

By following these guidelines and consulting with your healthcare provider regularly, you can maximize the benefits of PANRIDEN DSR while minimizing potential risks.