🔬 Uses and Benefits

Therapeutic Indications

UPRIDCAL K2-7 is primarily indicated for:

• Prevention and treatment of osteoporosis (age-related, post-menopausal, drug-induced)
• Calcium and vitamin D deficiency
• Bone fracture healing and prevention
• Support during pregnancy and lactation for maternal bone health
• Hypocalcemic conditions and vitamin D deficiency
• Management of osteopenia
• Supplementation in chronic kidney disease
• Support for patients on long-term corticosteroid therapy
• Calcium supplementation in elderly individuals
• Nutritional support for patients with malabsorption conditions

Benefits

• Comprehensive Bone Health: Provides multiple nutrients essential for bone formation and maintenance
• Enhanced Calcium Utilization: Vitamin K2-7 directs calcium to bones rather than soft tissues
• Cardiovascular Protection: Helps prevent arterial calcification through proper calcium metabolism
• Optimal Absorption: Contains active forms of vitamins for better bioavailability
• Neurological Support: Contains methylcobalamin and L-methylfolate for nervous system health
• Muscle Function: Magnesium and calcium support proper muscle contraction and relaxation
• Balanced Formula: Provides synergistic nutrients that work together for optimal effect
• Immune Support: Zinc contributes to immune system function
• Hormonal Health: Supports vitamin D metabolism and calcium regulation

📖 Instruction for Use

Dosage

• Standard Adult Dosage: 1 tablet/capsule daily or as directed by physician
• For Severe Deficiency: 1 tablet/capsule twice daily or as directed by physician
• Maintenance Therapy: 1 tablet/capsule daily

Administration

• Take UPRIDCAL K2-7 with a meal to enhance absorption
• Swallow whole with a full glass of water
• Best taken with the largest meal of the day (typically dinner)
• Maintain consistent timing each day for optimal results
• Do not crush or chew tablet/capsule unless specifically instructed by healthcare provider
• For patients with difficulty swallowing, consult healthcare provider for alternative forms

Duration of Treatment

• For deficiency: As prescribed by physician, typically 3-6 months with monitoring
• For prevention: Long-term use as directed by healthcare provider
• For osteoporosis management: Continuous therapy as advised
• For pregnancy/lactation: As prescribed throughout pregnancy and breastfeeding period

⏱️ Forget/Missed Doses

If you miss a dose of UPRIDCAL K2-7:

• Take it as soon as you remember on the same day
• If it's almost time for your next dose, skip the missed dose
• Do not double the dose to make up for a missed dose
• Return to regular dosing schedule
• If you miss doses frequently, set a daily reminder or link taking the medication to a daily routine (like brushing teeth)
• Missing occasional doses is unlikely to significantly impact long-term treatment outcomes

🧬 How this Works

UPRIDCAL K2-7 works through the complementary actions of its multiple components:

1. Calcitriol (0.25mcg):
   • The active form of vitamin D
   • Enhances intestinal absorption of calcium and phosphorus
   • Regulates calcium levels in the blood
   • Promotes bone mineralization
   • Influences parathyroid hormone secretion for calcium homeostasis
2. Calcium Carbonate (500mg):
   • Provides elemental calcium necessary for bone formation
   • Essential for muscle contraction, nerve transmission, and blood clotting
   • Serves as structural component of bones and teeth
   • Helps maintain bone mineral density
3. Vitamin K2-7 (45mcg):
   • Activates proteins that bind calcium to bone matrix (osteocalcin)
   • Prevents calcium deposition in arteries and soft tissues
   • Directs calcium toward bone tissue where it's needed
   • Complements vitamin D's action in calcium metabolism
   • Longer-acting form of vitamin K2 with better bioavailability
4. Mecobalamin (1500mcg):
   • Active form of vitamin B12
   • Essential for cell division including bone-forming cells
   • Supports proper nerve function
   • Plays a role in homocysteine metabolism
   • Supports red blood cell formation
5. L-Methylfolate (800mcg):
   • The active form of folate that's readily usable by the body
   • Works with B12 in homocysteine metabolism
   • Supports cellular growth and regeneration
   • Important for DNA synthesis and repair
   • More bioavailable than folic acid, especially in those with MTHFR gene variants
6. Zinc Sulphate Monohydrate (7.5mg):
   • Essential for bone formation and mineralization
   • Activates enzymes involved in bone metabolism
   • Supports immune function and wound healing
   • Plays a role in vitamin D metabolism
   • Required for collagen synthesis
7. Magnesium Hydroxide (50mg):
   • Critical for calcium metabolism and bone formation
   • Activates vitamin D, enhancing calcium absorption
   • Necessary for proper muscle and nerve function
   • Helps regulate calcium and potassium transport
   • Supports over 300 enzymatic reactions in the body

This comprehensive formula provides a synergistic approach to bone health by addressing multiple aspects of bone metabolism, calcium regulation, and supporting nutrients for optimal absorption and utilization.

🛡️ Storage

• Store UPRIDCAL K2-7 in a cool, dry place at temperature below 30°C (86°F)
• Keep away from direct sunlight and moisture
• Store in the original package or container until ready to use
• Keep bottle tightly closed when not in use
• Do not store in the bathroom or near the kitchen sink
• Keep out of sight and reach of children
• Do not use after the expiry date printed on the package
• Protect from excessive heat and humidity
• Do not remove the desiccant (if present in the bottle)

⚠️ Side Effects

Common Side Effects (generally mild and temporary)

• Mild gastrointestinal discomfort
• Constipation
• Nausea
• Flatulence or bloating
• Metallic taste

Less Common Side Effects

• Headache
• Dry mouth
• Upset stomach
• Mild allergic reactions (skin rash, itching)
• Changes in bowel movements

Serious Side Effects (seek immediate medical attention)

• Signs of hypercalcemia: excessive thirst, confusion, muscle weakness, bone pain
• Severe allergic reactions: swelling, severe dizziness, difficulty breathing
• Kidney stones or signs of kidney problems
• Unusual fatigue or weakness
• Irregular heartbeat
• Severe stomach pain
• Persistent nausea or vomiting

🔁 Over Doses

Symptoms of Overdose

• Severe nausea and vomiting
• Extreme thirst
• Dehydration
• Confusion
• Muscle weakness
• Abdominal pain
• Bone pain
• Lethargy and fatigue
• Irregular heartbeat
• In severe cases, kidney stones or kidney failure

Action in Case of Overdose

• Stop taking the medication immediately
• Contact emergency services or poison control center
• Drink plenty of water if conscious and able to swallow
• Do not attempt to induce vomiting unless specifically instructed by healthcare professionals
• Seek immediate medical attention
• Take the medication container with you when seeking medical help
• Treatment may include IV fluids, medications to lower calcium levels, and supportive care

💡 Safety Advice

Pregnancy and Breastfeeding

• Use during pregnancy and breastfeeding only under direct medical supervision
• Calcium and vitamin D requirements increase during pregnancy and lactation
• Dosage adjustments may be necessary based on individual needs
• Regular monitoring of calcium and vitamin D levels may be recommended
• Benefits typically outweigh risks when properly prescribed

Medical Conditions

Inform your doctor before taking UPRIDCAL K2-7 if you have:

• History of kidney stones or kidney disease
• Hypercalcemia (high calcium levels)
• Hypercalciuria (high calcium in urine)
• Heart disease
• Sarcoidosis
• Parathyroid disorder
• History of vitamin D toxicity
• Malabsorption syndromes
• Liver disease
• Blood clotting disorders (if on anticoagulant therapy)

Drug Interactions

UPRIDCAL K2-7 may interact with:

• Thiazide diuretics (may increase calcium levels)
• Digoxin (increased risk of toxicity with high calcium levels)
• Bisphosphonates (separate administration by at least 2 hours)
• Anticonvulsants (may affect vitamin D metabolism)
• Anticoagulants (potential interaction with vitamin K2)
• Certain antibiotics (may reduce absorption)
• Antacids containing aluminum (may interfere with phosphate absorption)
• Glucocorticoids (may counteract vitamin D effects)
• Cholestyramine (may reduce absorption)

Always inform all healthcare providers about all medications and supplements you are taking.

Additional Precautions

• Regular monitoring of calcium, phosphate, and vitamin D levels may be necessary during long-term use
• Drink adequate fluids to prevent kidney stone formation
• Maintain adequate but not excessive dietary calcium intake
• Avoid taking other calcium or vitamin D supplements unless specifically directed
• Exercise caution when taking with other multivitamins as this may lead to excessive intake
• People with absorption disorders may require dose adjustments
• Elderly patients may be more sensitive to side effects and require monitoring
• Maintain adequate hydration, especially in hot weather
• Report any unusual symptoms to healthcare provider promptly

UPRIDCAL K2-7 is a comprehensive bone health supplement that provides essential nutrients for calcium metabolism, bone formation, and maintenance. When taken as directed under appropriate medical supervision, it helps support skeletal health and may prevent osteoporotic conditions. Regular follow-up with healthcare providers is important to ensure optimal dosing and therapeutic benefit.