🔬 Uses and Benefits

Therapeutic Indications

UPRIDEN-P is indicated for:

• Relief of pain and inflammation in various conditions such as:
  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Dental pain
  • Musculoskeletal pain
  • Postoperative pain
  • Low back pain
  • Joint pain and inflammation
  • Mild to moderate pain associated with inflammation

Benefits

• Dual Action Pain Relief: Combines two different mechanisms for more effective pain management
• Anti-inflammatory Effect: Reduces swelling, redness, and inflammation in affected tissues
• Fever Reduction: Helps lower high body temperature when associated with pain conditions
• Synergistic Effect: The combination provides greater pain relief than either component alone
• Better Tolerability: The presence of paracetamol allows for effective pain relief with a potentially lower dose of aceclofenac

📖 Instruction for Use

Dosage

• Standard Adult Dosage: 1 tablet twice daily
• Or as prescribed by your physician

Administration

• Take UPRIDEN-P preferably with or after food to reduce stomach irritation
• Swallow the tablet whole with a full glass of water
• Take at approximately the same times each day for consistent effect
• Do not exceed the prescribed dosage or duration of treatment

Duration of Treatment

• Take for the shortest duration needed to control symptoms
• Long-term use should be monitored by a healthcare professional
• Regular assessment by your doctor is recommended for prolonged treatment

⏱️ Forget/Missed Doses

If you miss a dose of UPRIDEN-P:

• Take it as soon as you remember, if it's within a few hours of the scheduled time
• If it's almost time for your next dose, skip the missed dose and continue with your regular schedule
• Do not double the dose to make up for a forgotten tablet
• If you're unsure about what to do, consult your healthcare provider

Storage Instructions

• Store UPRIDEN-P in a cool, dry place, protected from light and moisture
• Keep at a temperature not exceeding 30°C (86°F)
• Keep the medication in its original packaging until time of use
• Store out of reach and sight of children
• Do not use after the expiry date stated on the package

🧬 How this Works

UPRIDEN-P works through the complementary actions of its two active components:

1. Aceclofenac (100mg):
   • A non-steroidal anti-inflammatory drug (NSAID)
   • Primarily inhibits cyclooxygenase-2 (COX-2) enzyme with lesser effect on COX-1
   • Blocks the production of prostaglandins that cause pain, inflammation, and fever
   • Also inhibits various inflammatory mediators like interleukin-1 (IL-1) and tumor necrosis factor (TNF)
   • Provides both peripheral analgesic and anti-inflammatory effects
2. Paracetamol (325mg):
   • Acts centrally as an analgesic and antipyretic agent
   • Inhibits prostaglandin synthesis primarily in the central nervous system
   • Possibly works through the serotonergic and cannabinoid systems
   • Provides additional pain relief through mechanisms different from NSAIDs
   • Enhances the overall analgesic effect with minimal gastrointestinal side effects

The combination targets different pain pathways simultaneously, offering more comprehensive relief than either medication alone.

🛡️ Storage

• Store UPRIDEN-P in a cool, dry place, protected from light and moisture
• Keep at a temperature not exceeding 25°
• Keep the medication in its original packaging until time of use
• Store out of reach and sight of children
• Do not use after the expiry date stated on the package

⚠️ Side Effects

Symptoms of Overdose

• Nausea, vomiting, stomach pain
• Drowsiness, confusion
• Liver damage (particularly due to paracetamol)
  • Early symptoms: Nausea, vomiting, excessive sweating, general malaise
  • Later symptoms (24-72 hours): Right upper quadrant pain, yellowing of skin/eyes

Action in Case of Overdose

• Seek immediate medical attention or contact a poison control center
• Take the medication package to show healthcare providers
• For paracetamol overdose, early intervention with N-acetylcysteine can be lifesaving

🔁 Over Doses

Symptoms of Overdose

• Nausea, vomiting, stomach pain
• Drowsiness, confusion
• Liver damage (particularly due to paracetamol)
  • Early symptoms: Nausea, vomiting, excessive sweating, general malaise
  • Later symptoms (24-72 hours): Right upper quadrant pain, yellowing of skin/eyes

Action in Case of Overdose

• Seek immediate medical attention or contact a poison control center
• Take the medication package to show healthcare providers
• For paracetamol overdose, early intervention with N-acetylcysteine can be lifesaving

💡 Safety Advice

Pregnancy and Breastfeeding

• Not recommended during pregnancy, especially in the third trimester
• Use during breastfeeding only if clearly necessary and under medical supervision
• Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding

Driving and Using Machines

• UPRIDEN-P may cause dizziness, drowsiness, or visual disturbances
• Do not drive or operate machinery if you experience these effects

Alcohol

• Avoid alcohol while taking UPRIDEN-P
• Alcohol increases the risk of gastrointestinal bleeding with aceclofenac
• Alcohol enhances the potential for liver damage with paracetamol

Medical Conditions

Inform your doctor before taking UPRIDEN-P if you have:

• History of stomach ulcers or gastrointestinal bleeding
• Heart disease, high blood pressure, or heart failure
• Kidney or liver problems
• Asthma or allergies to aspirin or other NSAIDs
• Blood clotting disorders
• Inflammatory bowel disease (Crohn's disease or ulcerative colitis)

Drug Interactions

UPRIDEN-P may interact with:

• Other NSAIDs or aspirin
• Anticoagulants (warfarin, heparin)
• Antihypertensive medications
• Diuretics
• Corticosteroids
• Selective serotonin reuptake inhibitors (SSRIs)
• Methotrexate
• Lithium
• Other paracetamol-containing products
• Quinolone antibiotics

Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements.

Additional Precautions

• Do not take other paracetamol-containing products while using UPRIDEN-P to avoid overdose
• Elderly patients may be more sensitive to side effects and may require dosage adjustment
• Regular monitoring of liver and kidney function is recommended during long-term treatment
• Stay well hydrated while taking this medication
• The medication may mask signs of infection or other underlying conditions
• Discontinue and seek medical attention if you develop severe skin reactions or other serious side effects

UPRIDEN-P provides effective relief from pain and inflammation through its dual-action formula, but should be used exactly as prescribed and under proper medical supervision to minimize potential side effects.