🔬 Uses and Benefits

UPRIDEN-SP is primarily indicated for:

• Reducing swelling and inflammation associated with surgery, trauma, and infection
• Relief of pain in various inflammatory conditions
• Management of bone and soft tissue injuries
• Relief of postoperative inflammation, swelling, and pain
• Treatment of conditions such as:
  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Dental pain
  • Postoperative pain
  • Musculoskeletal pain

Benefits

• Multi-modal Pain Relief: Combines three different mechanisms of action for effective pain management
• Reduced Inflammation: Helps decrease swelling, redness, and inflammation
• Enhanced Recovery: Promotes faster healing by reducing inflammation and breaking down inflammatory proteins
• Improved Mobility: Helps restore movement in joints affected by inflammation
• Comprehensive Treatment: Addresses both pain and underlying inflammation simultaneously

📖 Instruction for Use

Dosage

• Standard Adult Dosage: 1 tablet twice daily
• Or as prescribed by your physician

Administration

• Take UPRIDEN-SP preferably 2 hours after meals
• Swallow the tablet whole with a full glass of water
• Do not crush, break, or chew the tablet (to preserve the enteric coating of serratiopeptidase)
• Take at approximately the same times each day for best effect

Duration of Treatment

• Take for the shortest duration needed to control symptoms
• Long-term use should be monitored by a healthcare professional
• Follow your doctor's instructions regarding treatment duration

⏱️ Forget/Missed Doses

If you miss a dose of UPRIDEN-SP:

• Take it as soon as you remember, if it's within a few hours of the scheduled time
• If it's almost time for your next dose, skip the missed dose and continue with your regular schedule
• Do not double the dose to make up for a forgotten tablet
• If you're unsure, consult your healthcare provider

🧬 How this Works

UPRIDEN-SP works through the complementary actions of its three components:

1. Aceclofenac (100mg):
   • A non-steroidal anti-inflammatory drug (NSAID)
   • Inhibits cyclooxygenase (COX) enzymes, primarily COX-2
   • Blocks the production of prostaglandins that cause pain, inflammation, and fever
   • Provides strong anti-inflammatory and analgesic effects
2. Paracetamol (325mg):
   • Acts centrally as an analgesic and antipyretic
   • Inhibits prostaglandin synthesis in the central nervous system
   • Complements the peripheral action of aceclofenac
   • Provides additional pain relief with fewer gastrointestinal side effects than NSAIDs alone
3. Serratiopeptidase (15mg):
   • A proteolytic enzyme derived from bacteria
   • Breaks down protein byproducts of inflammation (like fibrin)
   • Reduces fluid buildup in inflamed tissues
   • Helps thin fluids and improve drainage from swollen areas
   • Enhances the penetration of antibiotics into infected tissues

The combined effect is more comprehensive than any single component alone, targeting multiple pathways involved in pain and inflammation.

🛡️ Storage

• Store UPRIDEN-SP protected from light and moisture
• Keep at a temperature not exceeding 30°C (86°F)
• Keep the medication in its original packaging until time of use
• Store out of reach and sight of children
• Do not use after the expiry date stated on the package

⚠️ Side Effects

Common Side Effects (generally mild and temporary)

• Gastrointestinal disturbances: Indigestion, stomach pain, nausea, diarrhea
• Dizziness or headache
• Fatigue or drowsiness
• Loss of appetite

Less Common Side Effects

• Flatulence or constipation
• Mild skin rash or itching
• Sleep disturbances

Serious Side Effects (seek medical attention immediately)

• Signs of gastrointestinal bleeding: Black/tarry stools, vomiting blood
• Severe skin reactions: Widespread rash, blisters, peeling skin
• Signs of liver problems: Yellowing of skin/eyes, dark urine, persistent fatigue
• Signs of allergic reaction: Swelling of face/throat, difficulty breathing
• Unusual bleeding or bruising
• Severe abdominal or stomach pain
• Vision or hearing changes

🔁 Over Doses

Symptoms of Overdose

• Nausea, vomiting, stomach pain
• Drowsiness, confusion, seizures
• Liver damage (particularly due to paracetamol)
• Respiratory difficulties
• Low blood pressure

Action in Case of Overdose

• Seek immediate medical attention or contact a poison control center
• Take the medication package with you to show healthcare providers
• Do not induce vomiting unless directed by medical professionals

💡 Safety Advice

Pregnancy and Breastfeeding

• Not recommended during pregnancy, especially in the third trimester
• Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding

Driving and Using Machines

• UPRIDEN-SP may cause dizziness, drowsiness, or visual disturbances
• Do not drive or operate machinery if you experience these effects

Alcohol

• Avoid alcohol while taking UPRIDEN-SP
• Alcohol increases the risk of stomach irritation and liver damage

Medical Conditions

Inform your doctor before taking UPRIDEN-SP if you have:

• History of stomach ulcers or bleeding
• Heart, kidney, or liver problems
• High blood pressure
• Asthma or allergies to aspirin or other NSAIDs
• Blood clotting disorders
• Upcoming surgery (discontinue at least 2 weeks before)

Drug Interactions

UPRIDEN-SP may interact with:

• Other NSAIDs or aspirin
• Blood thinners (warfarin, clopidogrel)
• Lithium
• Diuretics or blood pressure medications
• Methotrexate
• Corticosteroids
• Other paracetamol-containing products
• Certain antidepressants

Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements.

Additional Precautions

• Do not take other paracetamol-containing products while using UPRIDEN-SP to avoid overdose
• The elderly may be more susceptible to side effects and may require dose adjustment
• Not recommended for use in children
• Complete the full course as prescribed, even if symptoms improve
• Regular monitoring of liver and kidney function may be needed with long-term use

UPRIDEN-SP provides effective relief from pain and inflammation through its triple-action formula, but should be used exactly as prescribed under proper medical supervision to minimize potential side effects.